Chapter category: Transplant
Perfusion and Storage Techniques
Organ Preservation for Transplantation,
Third Edition
Edited by: Luis H. Toledo-PereyraISBN: TBA
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Chapter authors:
Amer Rajab, Ronald P Pelletier and Mitchell L Henry
The clinical practice of living‑related renal transplantation became firmly established by the late 1960s to early 1970s. However, it quickly became apparent that the need for transplantable kidneys far exceeded the availability. Subsequent legislation made it possible for people meeting the criteria of “brain death” to donate their organs to chronic renal failure patients who had easier access to these organs. As a result of these changes, a need arose for the development of organ preservation methods that would facilitate the successful transplantation of these cadaveric organs. In 1935, Lindbergh and Carrel were the first to describe organ preservation, utilizing a normothermic, pressurized and oxygenated solution system. Nearly 30 years later, Calne et al reported adequate kidney preservation for 8‑12 hours using simple cold storage in 1963. Soon thereafter, Folkert Belzer et al reported a successful human kidney transplant following preservation with a hypothermic, cryoprecipitated‑plasma perfusion method refined in the laboratory. To date, there continues to be debate among transplant physicians regarding simple cold storage versus machine perfusion as the preferred method of kidney preservation.
Amer Rajab
Ronald P Pelletier
Mitchell L Henry
Professor of Surgery, The Ohio State University Medical Center, Division of Transplantation and Comprehensive Transplant Center
Additional chapters from this book:
Cellular and Molecular Biology in Organ Ischemia‑Reperfusion Injury
Shohachi Suzuki
Ischemia‑reperfusion injury (IRI) is a multifactorial disorder which leads to cellular damage and organ dysfunction. A vast number of studies on IRI have shown that this critical pathophysiologi...
Science of Organ Preservation
Roberto Anaya-Prado, Luis H. Toledo-Pereyra and Juan M. Palma-Vargas
The goal of organ preservation is to obtain perfect preservation for as long as needed. Unfortunately, this has not been accomplished for the majority of organs; although the use of different techniqu...
Perfusion and Storage Techniques
Amer Rajab, Ronald P Pelletier and Mitchell L Henry
The clinical practice of living‑related renal transplantation became firmly established by the late 1960s to early 1970s. However, it quickly became apparent that the need for transplantable kid...
Pancreas Preservation
Shinichi Matsumoto, Hirofumi Noguchi, Naoya Kobayashi, Angelika Gruessner and David E.R. Sutherland
Pancreas preservation is an essential process prior to both pancreas transplantation and islet isolation. Traditionally, research on pancreas preservation focused on pancreas transplantation. Recently...
Metabolic Management
Sufan Chien
The removal of an organ, which is subjected to an unnatural environment necessitates special management strategies that differ from in vivo management. The normal human body and the bodies of other ma...
