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The PACSIN Proteins and their Role in Membrane Trafficking

This chapter appears in the following book:

The Pombe Cdc15 Homology Proteins

Edited by: Pontus Aspenström
ISBN: TBA
» Get more information about this book at landesbioscience.com «

Chapter authors:
Markus Plomann, Matthias Mörgelin and Sylvia Schael


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PACSIN 1/syndapin 1 was originally identified by its drastic expression decrease during CNS repair processes and by virtue of its binding to the GTPase dynamin. The three family members play important roles as accessory proteins in clathrin‑mediated endocytosis. They differ in tissue distribution and developmental expression, but share many interaction partners and their ability to bind to lipid surfaces. Besides contributing to membrane deformation PACSIN proteins play a key function as adaptor proteins, coupling various components of the clathrin‑assisted uptake with the actin polymerization machinery. Although many molecules are able to link both processes, the role of PACSINs in recognizing and regulating specific cargo molecules is only now beginning to be understood. Recent functional studies using a wide range of cells and tissues have revealed a crucial role for PACSIN proteins as modulators of receptor function by controlling their internalization and/or recycling. Current knowledge regarding PACSIN functions is reviewed here.

Markus Plomann
Institute for Biochemistry 2, Medical Faculty, University of Cologne

Matthias Mörgelin

Sylvia Schael

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Additional chapters from this book:

The PACSIN Proteins and their Role in Membrane Trafficking

Markus Plomann, Matthias Mörgelin and Sylvia Schael

PACSIN 1/syndapin 1 was originally identified by its drastic expression decrease during CNS repair processes and by virtue of its binding to the GTPase dynamin. The three family members play important...

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