Chapter category:
The Use of Leptin for the Treatment of Lipodystrophy
Leptin and Leptin Antagonists
Edited by: Arieh GertlerISBN: TBA
» Get more information about this book at landesbioscience.com «
Chapter authors:
Angeline Y. Chong, Elaine K. Cochran and Phillip Gorden
Leptin was the first of the adipocyte‑secreted hormones, later termed adipokines, to be identified. It is used clinically to treat hypoleptinemic states, such as congenital leptin deficiency and lipodystrophy. In this chapter, we discuss the effects of leptin administration in patients with lipodystrophy. Leptin markedly improves hyperglycemia, hypertriglyceridemia and insulin resistance. It normalizes menses in women and increases testosterone secretion in men. It also ameliorates hepatic and muscular steatosis. Studying the effects of leptin replacement in lipodystrophy may lead to the discovery of new and broader clinical applications of leptin therapy.
Angeline Y. Chong
Elaine K. Cochran
Phillip Gorden
National Intstitute of Health, Bethesda, Maryland
Additional chapters from this book:
The Use of Leptin for the Treatment of Lipodystrophy
Angeline Y. Chong, Elaine K. Cochran and Phillip Gorden
Leptin was the first of the adipocyte‑secreted hormones, later termed adipokines, to be identified. It is used clinically to treat hypoleptinemic states, such as congenital leptin deficiency and...
Study of Leptin: Leptin Receptor Interaction by FRET and BRET
Julie Dam, Cyril Couturier, Patty Chen and Ralf Jockers
Understanding the molecular mechanism of the leptin:leptin receptor (OB‑R) interaction and the OB‑R activation process is crucial for the development of drugs that target OB‑Rs. Rece...
Leptin as a Novel Marker in Breast and Colorectal Cancer
Eva Surmacz and Mariusz Koda
Obesity, defined as Body Mass Index (BMI) ≥30, constitutes a known risk factor for the development of different neoplasms, including such common diseases as postmenopausal breast cancer and colo...
Leptin Signal Transduction—A 2008 Update
Walter Becker
Leptin is an adipocyte‑secreted hormone that informs the brain about the status of the body’s energy stores. Leptin controls energy homeostasis through effects on satiety and energy expenditure ...
Is Leptin a Pro‑ or Anti‑Apoptotic Agent?
Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati and Clifton A. Baile
Apoptosis, the regulated destruction of a cell, is characterized by biological and morphological changes and involves a large web of integrating pathways and factors. Apoptosis is necessary to elimina...
Involvement of Leptin in Arterial Hypertension
Jerzy Beltowski
Leptin is secreted by white adipose tissue and its concentration in plasma is higher in obese than in lean subjects. Recent studies suggest that leptin is involved in cardiovascular complications of o...
Insights in the Activated LR Complex and the Rational Design of Antagonists
Frank Peelman, Lennart Zabeau and Jan Tavernier
The hormone leptin plays an important role in the control of body weight. Leptin is mainly produced and secreted by adipocytes as a 16 kDa nonglycosylated polypeptide and plasma leptin levels positive...
Leptin Actions in the Gastrointestinal Tract
Sandra Guilmeau, Thomas Aparicio, Robert Ducroc and André Bado
The primary physiological role of leptin is to communicate to the central nervous system (CNS) the abundance of available energy stores and to restrain food intake and induce energy expenditure.1̴...
The Role of Leptin in Bone Development and Growth
Efrat Monsonego Ornan and Michal Ben-Ami
The link between obesity and osteoporosis—two major public‑health problems, has become central to bone research in recent years, ever since leptin was identified as a regulator of both appetite ...
Involvement of Leptin in the Endometrial Function
Ana Cervero and Carlos Simon
Leptin was discovered in 1994 as the product of the OB gene and was originally thought to be produced by only adipocytes governing energy homeostasis. Nevertheless, it has since been described as a pl...
