Chapter category:
Transcriptional Regulation of their Survival: The Engrailed Homeobox Genes
Development and Engineering of Dopamine Neurons
Edited by: R. Jeroen Pasterkamp, Marten P. Smidt and J. Peter H. BurbachISBN: TBA
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Chapter authors:
Horst H. Simon and Kambiz N. Alavian
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Horst H. Simon
Department of Neuroanatomy, Interdisciplinary Center for Neuroscience (IZN), University of Heidelberg
Kambiz N. Alavian
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The brain contains a number of distinct regions that share expression of dopamine (DA) and its requisite biosynthetic machinery, but otherwise encompass a diverse array of features and functions. Acro...
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Meso‑diencephalic dopamine neurons (mdDA) neurons are located in the retrorubral field (RRF), substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) and give rise to prominent asc...
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The mammalian Engrailed genes were originally cloned by their sequence homology to the Drosophila engrailed. Orthologous genes of these homeobox transcription factors are found throughout the animal k...
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The orphan nuclear hormone receptor Nurr1 and the homeobox Pitx3 were the first two transcription factors that were implicated in the development of mesodiencephalic dopaminergic (mdDA) neurons.1,2 Th...
Foxa1 and Foxa2 Transcription Factors Regulate Differentiation of Midbrain Dopaminergic Neurons
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Midbrain dopaminergic neurons (mDA), comprising the substantia nigra pars compacta (A8), the ventral tegmental area (A9) and the retrorubal field (A10) subgroups, are generated from floor plate progen...
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Stem cells are defined by their ability to self‑renew and to differentiate into specific specialized cell types. Pluripotent stem cells such as embryonic stem cells are capable of differentiatin...
