Chapter category:
Leptin Signal Transduction—A 2008 Update
Leptin and Leptin Antagonists
Edited by: Arieh GertlerISBN: TBA
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Chapter authors:
Walter Becker
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Walter Becker
Institute of Pharmacology and Toxicology, Medical Faculty of the RWTH Aachen University, Aachen, Germany.
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Additional chapters from this book:
The Use of Leptin for the Treatment of Lipodystrophy
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Leptin was the first of the adipocyte‑secreted hormones, later termed adipokines, to be identified. It is used clinically to treat hypoleptinemic states, such as congenital leptin deficiency and...
Study of Leptin: Leptin Receptor Interaction by FRET and BRET
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Understanding the molecular mechanism of the leptin:leptin receptor (OB‑R) interaction and the OB‑R activation process is crucial for the development of drugs that target OB‑Rs. Rece...
Leptin as a Novel Marker in Breast and Colorectal Cancer
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Obesity, defined as Body Mass Index (BMI) ≥30, constitutes a known risk factor for the development of different neoplasms, including such common diseases as postmenopausal breast cancer and colo...
Leptin Signal Transduction—A 2008 Update
Walter Becker
Leptin is an adipocyte‑secreted hormone that informs the brain about the status of the body’s energy stores. Leptin controls energy homeostasis through effects on satiety and energy expenditure ...
Is Leptin a Pro‑ or Anti‑Apoptotic Agent?
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Apoptosis, the regulated destruction of a cell, is characterized by biological and morphological changes and involves a large web of integrating pathways and factors. Apoptosis is necessary to elimina...
