Chapter category:
The role of FasL and Fas in Health and Disease
Therapeutic Targets
of the TNF Superfamily
Edited by: Iqbal GrewalISBN: TBA
» Get more information about this book at landesbioscience.com «
Chapter authors:
Martin Ehrenschwender and Harald Wajant
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Martin Ehrenschwender
Departement of Molecular Internal Medicine
Medical Clinic and Polyclinic II
University of Wuerzburg
Harald Wajant
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Tumor necrosis factor (TNF)-related cytokines function as key communication systems between cells of the immune system and mediate inflammation and tissue destruction. LIGHT (TNFSF14) is a key compone...
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Vascular endothelial growth inhibitor (VEGI, TNFSF‑15) is a novel member of the tumor necrosis factor (TNF) superfamily that consists of 174 amino acids and exhibits a 20% to 30% sequence homolo...
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CD40 was originally identified as a receptor on B-cells that delivers contact‑dependent T helper signals to B-cells through interaction with CD40 ligand (CD40L, CD154). The pivotal role played b...
The role of FasL and Fas in Health and Disease
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The FS7‑associated cell surface antigen (Fas, also named CD95, APO‑1 or TNFRSF6) attracted considerable interest in the field of apoptosis research since its discovery in 1989. The groups ...
