Bioscience Chapter Database :: 3635 Chapters Now Online

Chapter category:

Lipoxins as an Immune‑Escape Mechanism

This chapter appears in the following book:

Pathogen-Derived Immunomodulatory Molecules

Edited by: Padraic Fallon
ISBN: TBA
» Get more information about this book at landesbioscience.com «

Chapter authors:
Fabiana S. Machado and Julio Aliberti


[+] view image
Here, we discuss the mechanisms of repression of signaling pathways that are triggered by Lipoxin (LX) and are responsible for control of pro‑inflammatory response during chronic phase of Toxoplasma gondii infection. We also discuss this mechanism from the perspective of the pathogen, which pirates the host’s lipoxygenase machinery to its own advantage as a probable immune‑escape mechanism. Pro‑inflammatory mediators such as IL‑12, IFN‑γ and TNF are essential in controlling parasite growth during T. gondii infection. However, it is clear that exacerbated production of these cytokines results in host tissue damage. LX, an anti‑inflammatory eicosanoid, plays an important role in regulation of immune response to T. gondii.

Fabiana S. Machado
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine

Julio Aliberti
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine

» Download Open Access Chapter



Additional chapters from this book:

Innate Immune Evasion by Staphylococci

Karin Ellen Veldkamp and Jos A.G. van Strijp

When bacteria invade the human host, they are directly confronted with a serious threat, the human innate immune system. This chapter describes the challenge that a staphylococci face and recent findi...

The Immunosuppresive Tick Salivary Protein, Salp15

Ignacio J. Juncadella and Juan Anguita

The interaction between Ixodid ticks and their mammalian hosts is a complex relationship. While the mammalian host tries to avoid the completion of the feeding process, the tick has devised strategies...

Bacterial Complement Escape

Ilse Jongerius, Sanjay Ram and Suzan Rooijakkers

Complement activation is a crucial step in our innate immune defense against invading bacteria. Complement proteins can quickly recognize invading bacteria and subsequently label them for phagocytosis...

Immunomodulatory Activity and Therapeutic Potential of the Filarial Nematode Secreted Product, ES‑62

William Harnett and Margaret M. Harnett

ES‑62 is a protein that is actively secreted by filarial nematodes during parasitism of the vertebrate host. The molecule is able to directly interact with a number of cells of the immune system...

Viral TNF Inhibitors as Potential Therapeutics

Masmudur M. Rahman, Alexandra R. Lucas and Grant McFadden

The immune system functions by maintaining a delicate balance between the activities of pro‑inflammatory and anti‑inflammatory pathways. Unbalanced activation of these pathways often leads...

Modulation of Innate Immune Signalling Pathways by Viral Proteins

Orla Mulhern, Barry Harrington and Andrew G. Bowie

In recent years an explosion of information on the various strategies viruses employ to penetrate and hijack the host cell has led to an increased understanding of both viruses themselves and the host...

Bacterial Toxins as Immuno‑Modulators

David S. Donaldson and Neil A. Williams

Bacterial toxins are the causative agent of pathology in a variety of diseases. Although not always the primary target of these toxins, many have been shown to have potent immuno‑modulatory effe...

Lipoxins as an Immune‑Escape Mechanism

Fabiana S. Machado and Julio Aliberti

Here, we discuss the mechanisms of repression of signaling pathways that are triggered by Lipoxin (LX) and are responsible for control of pro‑inflammatory response during chronic phase of Toxopl...

Fungal-Derived Immune Modulating Molecules

Tania C. Sorrell and Sharon C.A. Chen

Invasive fungal infections are an increasing clinical problem for which new therapeutic approaches are needed. Understanding the initial interaction between fungi and the host offers potential for dev...

Helminthic Therapy: Using Worms to Treat Immune‑Mediated Disease

David E. Elliot and Joel V. Weinstock

There is an epidemic of immune‑mediated disease in highly‑developed industrialized countries. Such diseases, like inflammatory bowel disease, multiple sclerosis and asthma increase in prev...

The Serpin Saga; Development of a New Class of Virus Derived Anti‑inflammatory Protein Immunotherapeutics

Alexandra Lucas, Liying Liu, Erbin Dai , Ilze Bot, Kasinath Viswanathan, Ganesh Munuswamy-Ramunujam, Jennifer A. Davids, Mee Y. Bartee, Jakob Richardson, Alexander Christov, Hao Wang, Colin Macaulay, Mark Poznansky, Robert Zhong, L. Miller, Erik Biessen, Mary Richardson, Colin Sullivan, Richard Moyer, Mark Hatton, David A. Lomas and Grant McFadden

Serine proteinase inhibitors, also called serpins, are an ancient grouping of proteins found in primitive organisms from bacteria, protozoa and horseshoe crabs and thus likely present at the time of t...


SIGN IN

Email:


Password:


lost password?




[ Home | Authors | Editors | Custom Books | Chapter Reprints | Subscribe | Contact | Biotoons ]