Chapter category: Medical
Developing Pharmacological Modulators of STAT Signaling
JAK-STAT Pathway in Disease
Edited by: Anastasis StephanouISBN: TBA
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Chapter authors:
Erik A. Nelson and David A. Frank
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Erik A. Nelson
David A. Frank
Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Additional chapters from this book:
STATs and Infection
Silvia Stockinger and Thomas Decker
The seven members of the mammalian signal transducer and activator of transcription (STAT) family participate in a wide range of biological processes with impact both on the generation and the functio...
STAT Protein Regulation of Inflammatory T-Helper Cell Phenotypes
Mark H. Kaplan and John T. O'Malley
The stability and commitment of T-helper cells is controlled by three factors; the cytokines present in the microenvironment, the acquisition and/or downregulation of cytokine receptors on the surface...
Janus Kinase (JAK)‑Signal Transducer and Activator of Transcription (STAT) Pathway in Heart Disease
Aneta E. Rybka, Anastasis Stephanou and Paul A. Townsend
The JAK‑STAT (Janus Kinases‑Signal Transducers and Activators of Transcription) intracellular signal transduction pathway plays a critical role in many human disease scenarios and especial...
Suppressors of Cytokine Signaling: Functions in Normal Biology and Roles in Disease
Anna C. Barry, Lynda A. O'Sullivan and Alister C. Ward
Suppressor of cytokine signaling (SOCS) proteins have been identified as key negative regulators of cytokine and growth factor signaling. Therefore, given the diverse roles played by cytokines and gro...
Developing Pharmacological Modulators of STAT Signaling
Erik A. Nelson and David A. Frank
As cancer continues to cause over 500,000 deaths per year in the United States alone, it is clear that the cytotoxic drugs commonly in use for cancer treatment are not adequately effective. As we have...
Stat5 as Hematopoietic Gatekeeper and Oncogene Upon Tyrosine Kinase‑Induced Transformation
Katrin Friedbichler, Marc A. Kerenyi, Ernst W. Müllner and Richard Moriggl
The transcription factors Stat5a and Stat5b are crucial gene regulators for all hematopoietic cell types. Stat5 proteins play essential roles in hematopoietic stem cell maintenance as well as lineage ...
STAT1 and STAT3 in Tumorigenesis: Two Sides of the Same Coin?
Sara Pensa, Gabriella Regis, Daniela Boselli, Francesco Novelli and Valeria Poli
The transcription factors STAT1 and STAT3 appear to play opposite roles in tumorigenesis. While STAT3 promotes cell survival/proliferation, motility and immune tolerance and is considered as an oncoge...
The Role of the JAK/STAT Pathway in Inflammatory Bowel Diseases
Raja Atreya and Markus F. Neurath
Although the exact pathogenic mechanisms in inflammatory bowel diseases (IBD) still remain unclear, increasing evidence has implicated proinflammatory cytokines and their related transcription factors...
JAK/STAT Pathway Signalling in Drosophila Melanogaster
Samira Bina and Martin Zeidler
Drosophila melanogaster is a developmentally and genetically highly tractable animal model and many significant advances in the field of signal transduction have been made and elucidated in this syste...
STAT1 and STAT3:Opposing Roles in Cell Death and Cell Cycle Regulation
Anastasis Stephanou, R. A. Knight and D.S. Latchman
The signal transducers and activators of transcription (STATs) are a family of transcription factors which were originally identified on the basis of their ability to transduce a signal from a cellula...
STAT 5 - Mediated Self-Renewal of Normal and Leukemic Stem Cells
Jan Jacob Schuringa
The level of transcription factor activity critically regulates cell fate decisions such as hematopoietic stem cell self‑renewal and differentiation. The balance between hematopoietic stem cell ...
