Chapter category: Heat Shock Proteins
Role of Heat Shock Proteins, Protein Kinase C and ATP-Sensitive Potassium Channel in Delayed Myocardial Protection
Heat Shock Proteins in Myocardial Protection
Edited by: Rakesh C. KukrejaISBN: 1-58706-021-3
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Chapter authors:
Rakesh C. Kukreja, Yong-Zhen Qian and Jeffery B. Hoag
Heat shock proteins (Hsp's) are one of the highly conserved proteins in existence, found in every organism.1 These proteins are synthesized quickly and intensely in response to stressors and are known to protect the cells from the toxic effects of heat and other stresses.2 There has been a tremendous interest in the role of Hsp's to understand their function under stress conditions as well as homeostatic states. Exactly how Hsp's protect cells is unclear; however, several explanations have been offered. These include the renaturation of damaged proteins, or facilitation of the folding and targeting of newly synthesized proteins to organelles.2,3 Hsp's may also maintain newly synthesized proteins in a translocational configuration (linear or unfolded).4 After heat stress the cytoplasmic Hsp 72 is found to localize in and around the nucleus but move back out to the cytoplasm during the recovery phase. Hsp 72 and 73 bind transiently to nascent proteins acting as intracellular chaperones and help stabilize these proteins until they achieve their final conformation.5
Additional chapters from this book:
Ischemia/Reperfusion Injury and Heat Shock Proteins
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Physiological Role of Heat Shock Protein 27
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Heat shock protein 27 (Hsp27) is a stress–inducible cytosolic protein that is ubiquitously present in many normal cells. The synthesis of Hsp27 is induced by heat shock and other envir...
Stress Proteins in Myocardial Protection: Culture Shock Protein, Heme Oxygenase–1 (Hsp32), Induced by Sublethal Stresses Protects the Heart Against Oxidative Stress
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The formation of a stress protein comprises a mechanism of cell protection highly conserved in evolution. As the induction of stress proteins makes cells more tolerant towards a second, mor...
Antisense, Heat Shock Proteins and the Heart
A. A. Knowlton
Antisense technology provides a tool with which to dissect the components of the stress response. There are two known endogenous sets of protective proteins, the heat shock proteins (Hsps) and...
Preconditioning of Cardiac Myocytes: Studies Using Cultured Neonatal
Jan A. Post, Chris T.W.M. Schneijdenberg and Arie J. Verkleij
The acquisition of tolerance towards myocardial ischemia and reperfusion can be acquired by several preconditioning procedures. The original preconditioning protocol described for myocardia...
Hsp72 in the Regulation of TNF–a Production:
Xianzhong Meng
Myocardial ischemia/reperfusion induces the production of the cardiac depressant cytokine tumor necrosis factor–a (TNF–a). Macrophages (M
Hsp70 and Ischemia Tolerance in the Compromised Heart Ger J. van der Vusse
Luc H.E.H. Snoeckx, Richard N.M. Cornelussen, Robert S. Reneman and
The discovery in eukaryotic and prokaryotic organisms of a prompt and specific response to heat shock, known as the heat shock response, has stimulated the development of a complete new res...
Role of Heat Shock Proteins, Protein Kinase C and ATP-Sensitive Potassium Channel in Delayed Myocardial Protection
Rakesh C. Kukreja, Yong-Zhen Qian and Jeffery B. Hoag
Heat shock proteins (Hsp's) are one of the highly conserved proteins in existence, found in every organism.1 These proteins are synthesized quickly and intensely in response to stre...
Cardioprotection by Stress Proteins
Heat Shock Proteins in Myocardial Protection, edited by Rakesh C. Kukreja
Myocardial ischemia causes a series of changes at the intracellular level within the cardiomyocyte. These intracellular changes include changes in calcium levels, altered osmotic control, memb...
Heat Stress Proteins: A Possible Route to Myocardial Protection
Mohamed Amrani, Caroline C. Gray and Magdi H. Yacoub
Heat stress proteins (hsp) are induced by a variety of stimuli including elevated temperature,1 ischemia,2 hypoxia,3 pressure overload4 and some ...
Stress Proteins in Myocardial Protection
Richard Carroll and Derek M. Yellon
In all organisms examined heat stress results in the synthesis of a specific group of proteins known as the heat shock or stress proteins (Hsps). Cells that accumulate these proteins adapt ...
