Chapter category: Cancer Metastasis

Keratinocyte Interactions with Fibronectin during Wound Healing

This chapter appears in the following book:

Cell Invasion

Edited by: Jyrki Heino and Veli-Matti Kähäri
ISBN: 1-58706-073-6
» Get more information about this book at landesbioscience.com «

Chapter authors:
H. Larjava, L. Koivisto and L. Häkkinen

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_Reepithelialization of wounds is critical for survival. After injury, fibronectinfibrin clot is formed. Keratinocytes become activated and start migrating into the clot. Migration involves coordinate expression of several new extracellular matrix molecules, fibronectin receptors and proteinases. Migrating keratinocytes express alternatively spliced EDA fibronectin while both EDA and EDB fibronectin isoforms are found in the granulation tissue. Fibronectins are assembled into polymerized matrix that is further crosslinked to fibrin and these multimeric complexes of fibronectins have their own specific effects on cell signaling. Upon wounding, keratinocytes express three new fibronectin receptors, namely a5b1, avb6 and avb1 integrins. Integrin a5b1 recognizes the RGD sequence and the synergy site of fibronectin and plays a critical role in the early migration. Interestingly, an important role for the synergy site in keratinocyte migration has been proposed. In addition to cell migration, a5b1 integrin also regulates expression of dozens of genes important for a variety of cell functions including cell growth. Integrin avb 6 also mediates cell adhesion on fibronectin and it can functionally replace a5b1 integrin. The most important function of avb6 may be, however, to activate TGFb during late wound healing. Laminin5 and tenascinC are also expressed by the migrating keratinocytes. These cells have three laminin5 and two putative tenascinC receptors and their function needs to be spatially and temporally coordinated with the three fibronectin receptors. Elucidation of the mechanism of this coordination is crucial for better understanding of reepithelialization.

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Keratinocyte Interactions with Fibronectin during Wound Healing

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Chapter category: Cancer Metastasis

Keratinocyte Interactions with Fibronectin during Wound Healing

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