Chapter category: Angiogenesis
Anti-Angiogenesis Strategies: Potential Therapeutic Implications
Angiogenesis Inhibitors and Stimulators: Potential Therapeutic Implications
Edited by: Shaker A. MousaISBN: 1-58706-022-1
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Chapter authors:
Shaker A. Mousa
Angiogenesis is a process that is dependent upon coordinate production of angiogenesis stimulatory and inhibitory (angiostatic) molecules and any imbalance in this regulatory circuit might lead to the development of a number of angiogenesis-mediated diseases. Angiogenesis is a multistep process including: activation, adhesion, migration, proliferation and transmigration of endothelial cells across cell matrices to form new capillaries from existing vessels. In contrast, vessel rudiments may organize in place, a process termed vasculogenesis. Endothelial heterogeneity and organ specificity might contribute to differences in the response to different anti-angiogenic mechanisms (cultured EC vs. microvascular EC isolated from different tissues). Under normal physiological conditions, in mature organisms endothelial cell turnover or angiogenesis is extremely slow (months to years). However, angiogenesis can be activated for a limited time in certain situations such as wound healing and ovulation. In certain pathological states, such as metastasis (oncology) and ocular neovascularization disorders including diabetic retinopathy and age-related macular degeneration (opthamology) there is excessive and sustained angiogenesis. Hence understanding the mechanisms involved in the regulation of angiogenesis could have a major impact in the prevention and treatment of pathological angiogenesis processes. Additionally, endothelial cells play a major role in the modeling of blood vessels. The interplay of growth factors, cell adhesion molecules, matrix proteases and specific signal transduction pathways either in the maintenance of the quiescent state or in the reactivation of endothelial is critical in physiological and pathological angiogenesis processes.
Additional chapters from this book:
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Anti-Angiogenesis Strategies: Potential Therapeutic Implications
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Angiogenesis is a process that is dependent upon coordinate production of angiogenesis stimulatory and inhibitory (angiostatic) molecules and any imbalance in this regulatory circui...
Ocular Neovascularization
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Angiogenesis plays a critical role in embryonic development, the menstrual cycle, and wound repair. Exaggeration of its role in wound repair can result in pathologies such as retinal and choro...
Role of Angiogenesis in Wound Healing
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Angiogenesis, the formation of new blood vessels, is necessary for wound repair since the new vessels provide nutrients to support the active cells, promote granulation tissue forma...
Regulation of Angiogenesis by Fibroblast Growth Factors
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Polypeptide factors which directly influence the migratory and proliferative activity of the human endothelial cell in vitro are well recognized as mediators of human angiogenesis in vivo. It ...
The Role of Vascular Endothelial Growth Factor in Angiogenesis
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Thrombospondin and Angiogenesis
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Angiogenesis, the formation of new vessels from a preexisting vasculature depends critically on the ability of the capillary endothelial cells to sever their normal cellcell associations, to m...
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Mechanisms of Angiogenesis: Potential Therapeutic Targets
Shaker A. Mousa
The formation of new capillary blood vessels, a process termed "angiogenesis", is dependent upon coordinate production of angiogenesis promoters and suppressors. Angiogenesis is ...
