Chapter category: Angiogenesis
Pharmaceutical Development of an Antiangiogenic Drug-Candidate: Challenges and Opportunities
Angiogenesis Inhibitors and Stimulators: Potential Therapeutic Implications
Edited by: Shaker A. MousaISBN: 1-58706-022-1
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Chapter authors:
Marc Riviére, Violetta Dimitriadou, Gerald Batist and Éric Dupont
The development of antiangiogenic multifunctional drugs aims to make available to physicians and their patients a novel and effective therapy directly targeting angiogenesis-dependent pathologies for which current therapies are not optimal because of toxic effects or of only moderate efficacy. A variety of diseases can be targeted with the antiangiogenic approach, including cancer, inflammatory and cardiovascular diseases and autoimmune disorders (reviewed in refs. 1,2). In fact, more than 20 diseases have been identified as potential indication of this new approach.1,3 Since the cancer application of antiangiogenic therapy is the most advanced indication in terms of pharmaceutical development, in this chapter we will focus on the challenges and opportunities the development of this new therapeutic class offers pharmaceutical developers.
Additional chapters from this book:
Lessons from Clinical Trials of Anti-Angiogenic Drugs in the Treatment of Cancer
Maggie C. Lee, James Tomlinson and Mai Nguyen
The process of angiogenesis plays a critical role in tumor growth and metastasis. Recently, there has been much interest in the use of antiangiogenic drugs in the treatment of cancer. This cha...
Surrogate Endpoints as a Measure of Efficacy in Clinical Trials of Angiogenesis Inhibitors
Przemek Twardowski, Stephen Gately and William Gradishar
It is now generally accepted that solid tumor growth and metastases are dependent upon the acquisition of an adequate blood supply.1 Pharmacological targeting of tumor microvasculat...
Pharmaceutical Development of an Antiangiogenic Drug-Candidate: Challenges and Opportunities
Marc Riviére, Violetta Dimitriadou, Gerald Batist and Éric Dupont
The development of antiangiogenic multifunctional drugs aims to make available to physicians and their patients a novel and effective therapy directly targeting angiogenesis-dependent patholog...
Matrix Metalloproteinase Inhibitors in Angiogenesis-Mediated Disorders with Special Emphasis on Cancer
Henrik S. Rasmussen
Matrix metalloproteinases (MMPS) are a family of enzymes that are secreted by connective tissue cells, inflammatory phagocytes and a number of different transformed cells. They are ...
Anti-Angiogenesis Strategies: Potential Therapeutic Implications
Shaker A. Mousa
Angiogenesis is a process that is dependent upon coordinate production of angiogenesis stimulatory and inhibitory (angiostatic) molecules and any imbalance in this regulatory circui...
Ocular Neovascularization
Peter A. Campochiaro and Naba Bora
Angiogenesis plays a critical role in embryonic development, the menstrual cycle, and wound repair. Exaggeration of its role in wound repair can result in pathologies such as retinal and choro...
Role of Angiogenesis in Wound Healing
Hynda K. Kleinman and Katherine M. Malinda
Angiogenesis, the formation of new blood vessels, is necessary for wound repair since the new vessels provide nutrients to support the active cells, promote granulation tissue forma...
Regulation of Angiogenesis by Fibroblast Growth Factors
Carla Mouta Carreira, Francesca Tarantini, Igor Prudovsky, Susan Garfinkel and Thomas Maciag
Polypeptide factors which directly influence the migratory and proliferative activity of the human endothelial cell in vitro are well recognized as mediators of human angiogenesis in vivo. It ...
The Role of Vascular Endothelial Growth Factor in Angiogenesis
Napoleone Ferrara
The development of a vascular supply is a fundamental requirement for organ development and differentiation during embryogenesis as well as for wound healing and reproductive functions in the ...
Thrombospondin and Angiogenesis
Luisa A. DiPietro
Thrombospondin1 (TSP1) is an extracellular matrix molecule that is produced by numerous cell types, including endothelial cells, fibroblasts, macrophages, monocytes, keratinocytes, ...
PECAM-1 and Angiogenesis
Horace M. DeLisser
Angiogenesis, the formation of new vessels from a preexisting vasculature depends critically on the ability of the capillary endothelial cells to sever their normal cellcell associations, to m...
Integrin av in Health and Disease—Role of avb3 in Metastasis, Vascular Remodeling and Angiogenesis
Shaker A. Mousa, Judith A. Varner and David Cheresh
The invasion, migration, proliferation and survival of cells are now known to be regulated in part by members of the integrin family of cell adhesion proteins. The integrin family is composed ...
The Role of Smooth Muscle Cells and Pericytes in Angiogensis
Jennifer W. Walter and David C. Sane
The stages of angiogenesis have been defined on the basis of critical endothelial cell activities such as basement membrane proteolysis, cell migration, proliferation and tube formation.1...
Angiogenesis and Ischemia
Derrick S. Grant and Zofia Zukowska-Grojec
The vascular supply to limbs and peripheral tissues is essential for normal physiological functions. Under certain pathologic conditions, however, vascular supply may be reduced to such an ext...
Mechanisms of Angiogenesis: Potential Therapeutic Targets
Shaker A. Mousa
The formation of new capillary blood vessels, a process termed "angiogenesis", is dependent upon coordinate production of angiogenesis promoters and suppressors. Angiogenesis is ...
