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Chapter category: Cell Metabolism

Central Nervous System Innervation of Brown Adipose Tissue

This chapter appears in the following book:

Adipose Tissue

Edited by: Susanne Klaus
ISBN: 1-58706-040-X
» Get more information about this book at landesbioscience.com «

Chapter authors:
Timothy J. Bartness, C. Kay Song, Gregory E. Demas

Environmental factors such as ambient temperature and food availability can affect the survival and reproductive success of animals. This is especially important for small rodents with their increased metabolic rates compared with larger animals, and because of their increased heat loss due to high surface-to-volume ratios. A variety of physiological adaptations have evolved that buffer small mammals, and other animals including humans, against the inhibitory influences of cold exposure and food scarcity on reproductive functioning. Adipose tissues, in particular, appear to play a critical role in neutralizing the suppression of reproductive responses by cold temperatures or starvation. Specifically, brown adipose tissue (BAT) is the primary site of nonshivering thermogenesis, whereas white adipose tissue (WAT) is the largest source of internally stored energy in most mammals. Control of these and other tissues occurs via humoral or neural influences, or both. Thus, the growth and function of these adipose tissues is vital to the regulation of energy balance and therefore ultimately critical for reproductive success.

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Additional chapters from this book:

Adipose Tissue Pathology in Human Obesity

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Human obesity is characterized by an excess of adipose tissue mass that has potential adverse health consequences and may finally result in a reduced quality of life and life expectancy.

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We are currently undergoing a revolution in our perspectives on the physiological role of white adipose tissue (WAT). Traditionally, white fat has been viewed primarily as a longterm energy...

Heterogeneity of Adipose Tissue Metabolism

Michael Boschmann

Adipose tissue is a highly specialized organ dealing mainly with processes for storage and release of energy. The underlying metabolic routes of these processes are regulated by a complex netw...

Central Nervous System Innervation of White Adipose Tissue

Timothy J. Bartness, Gregory E. Demas, C. Kay Song

The incessant demand for energy by tissues, especially the central nervous system (CNS), is a challenge that must be met for normal physiological functioning and behavior to occur. This is an ...

Central Nervous System Innervation of Brown Adipose Tissue

Timothy J. Bartness, C. Kay Song, Gregory E. Demas

Environmental factors such as ambient temperature and food availability can affect the survival and reproductive success of animals. This is especially important for small rodents with their i...

Brown Adipocyte Differentiation and Function in Energy Metabolism

Susanne Klaus

Brown adipose tissue (BAT) is a specialized thermogenic adipose tissue with greatimportance for thermoregulation and cold defense of small mammals. As outlined in the previous chapter, the ...

Brown Adipose Tissue: Thermogenic Function and Its Physiological

Susanne Klaus

Brown adipose tissue (BAT) is a specialized form of adipose tissue whose function is opposite to classical white fat function. As a thermogenic tissue it is a site of energy dis...

Development of White Adipose Tissue and Adipocyte Differentiation

Gérard Ailhaud

In humans, the development of white adipose tissue (WAT) occurs to a large extent postnatally and continues throughout life, in contrast to the development of brown adipose tissue (BAT) which ...

Morphology of the Adipose Organ

Saverio Cinti

The white adipose tissue is composed of spherical cells with a diameter ranging from 15 to 150 µm (Fig. 2) in aldehyde-fixed and paraffin or resin embedded specimens.

This enormous...

Overview: Biological Significance of Fat and Adipose Tissues

Susanne Klaus

From a human point of view fat or adipose tissue is nowadays often considered assuperfluous and undesired, especially considering the current "emaciated" beauty ideal of the Western world. Thi...

Development of White Adipose Tissue and Adipocyte Differentiation

Gérard Ailhaud

In humans, the development of white adipose tissue (WAT) occurs to a large extent postnatally and continues throughout life, in contrast to the development of brown adipose tissue (BAT) which ...

Morphology of the Adipose Organ

Saverio Cinti

The adipose organ (Fig. 1) of mammals is composed of two different tissues: white and brown adipose tissues.13 In mammals these tissues are organized in disti...

Overview: Biological Significance of Fat and Adipose Tissues

Susanne Klaus

From a human point of view fat or adipose tissue is nowadays often considered assuperfluous and undesired, especially considering the current "emaciated" beauty ideal of the Western world. Thi...


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