Chapter category: Neuroscience
The Interaction of Neuropilin-1 and Neuropilin-2 with Tyrosine-Kinase Receptors or VEGF
Neuropilin: From Nervous System
to Vascular and Tumor Biology
Edited by: Dominique BagnardISBN: 0-306-47416-6
» Get more information about this book at landesbioscience.com «
Chapter authors:
Gera Neufeld, Ofra Kessler and Yael Herzog
The Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2) receptors were initially described as receptors for axon guidance factors belonging to the class-3 Semaphorin sub-family. Subsequently, it was found the Neuropilins also function as receptors for some forms of vascular endothelial growth factor (VEGF). VEGF165 binds to both NRP1 and to NRP2 but VEGF121 does not bind to either of these receptors. VEGF145 on the other hand, binds to NRP2 but not to NRP1. Additional VEGF family members such as the heparin binding form of placenta growth factor (PlGF-2) and VEGF-B bind to NRP1, and it was also shown that both PlGF-2 and VEGF-C bind to NRP2.
The intracellular domains of the Neuropilins are short, and do not suffice for independent transduction of biological signals subsequent to Semaphorin or VEGF binding. It was shown that both Neuropilins can form complexes with receptors belonging to the Plexin family, and that such Plexin/Neuropilin complexes are able to transduce signals following the binding of class-3 Semaphorins to Neuropilins. The VEGF165 induced proliferation and migration of cells that express the VEGF tyrosine-kinase receptor VEGFR2 is enhanced in the presence of NRP1, suggesting that Neuropilins may also form complexes with VEGF tyrosine-kinase receptors such as VEGFR2. However, it is not yet clear whether VEGFR2 and NRP1 form complexes and contrasting results have been reported with regard to this issue. In contrast, it was recently reported by two laboratories that Neuropilins can form complexes with the second tyrosine-kinase receptor of VEGF, VEGFR1. However, the biological function of these complexes is still unclear.
Additional chapters from this book:
Neuropilin and Class 3 Semaphorins in Nervous System Regeneration
Fred De Winter, Anthony J.G.D. Holtmaat and Joost Verhaagen
Injury to the mature mammalian central nervous system (CNS) is often accompanied by permanent loss of function of the damaged neural circuits. The failure of injured CNS axons to regenerate...
Neuropilin and its Ligands in Normal Lung and Cancer
Joëlle Roche, Harry Drabkin and Elisabeth Brambilla
Neuropilins (NRPs) are receptors for class 3 Semaphorins and function as co-receptors for Vascular endothelial growth factor isoforms, VEGF165 and VEGF145 and related mol...
The Function of Neuropilin / L1 Complex
V. Castellani
L1, a cell adhesion molecule of the Ig superfamily (IgCAM) plays a critical role in the formation of neuronal networks. This is reflected by the variety of clinical signs associated with the X...
The Interaction of Neuropilin-1 and Neuropilin-2 with Tyrosine-Kinase Receptors or VEGF
Gera Neufeld, Ofra Kessler and Yael Herzog
The Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2) receptors were initially described as receptors for axon guidance factors belonging to the class-3 Semaphorin sub-family. Subsequently, it wa...
The Function of Neuropilin/Plexin Complexes
Andreas W. Püschel
Neuropilins bind the secreted class 3 semaphorins with high affinity but require a member of the plexin family to form receptors that are able to activate downstream signal transduction cascad...
Structural and Functional Relation of Neuropilins
Fumio Nakamura and Yoshio Goshima
Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologues, Neuropilin-1 and -2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is w...
Neuropilin-1 in the Immune System
Paul-Henri Romeo, Valérie Lemarchandel and Rafaele Tordjman
The neuropilin-1 (NRP1) and neuropilin-2 (NRP2) receptors can bind the class-3 semaphorin subfamily and the heparin-binding forms of vascular endothelial growth factor (VEGF) and placenta grow...
The Role of Neuropilin in Vascular and Tumor Biology
Michael Klagsbrun, Seiji Takashima and Roni Mamluk
Neuropilin1 (NRP1) and NRP2 are related transmembrane receptors that function as mediators of neuronal guidance and angiogenesis. NRPs bind members of the class 3 semaphorin family, regulators...
Neuropilins as Semaphorin Receptors: In vivo Functions in Neuronal Cell
Anil Bagri and Marc Tessier-Lavigne
After the initial discovery of neuropilin-1 as an epitope on axons recognized by a monoclonal antibody, neuropilins were rediscovered in the search for receptors mediating the repulsive action...
From the Discovery of Neuropilin to the Determination of its Adhesion Sites
Hajime Fujisawa
Neuropilin (NRP) and plexin (Plex) that are now known to be semaphorin receptors were initially identified as antigens for monoclonal antibodies (MAbs) that bound to particular neuropiles and ...
