Chapter category: Neurodegenerative Disease
Neurochemical Indices of Functional Restoration
Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease
Edited by: Lazaros TriarhouISBN: 0-306-47435-2
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Chapter authors:
Lazaros C. Triarhou
A general asset of the weaver model is that one can study graft development at the same time as the animal's own dopamine (DA) system continues to undergo a progressive degeneration, which is reflected in the relatively slow loss of cells in the mutant, compared with the rapid and traumatic loss in neurotoxic lesion experiments. Adaptive changes to the striatal DA denervation also differ in many ways between the weaver mutant and the 6-hydroxydopamine (6-OHDA) model.1 In that respect, studies with lesion models2 and with genetic dissection through mutations3 may provide a complementary profile of graft effects and of graft-recipient interactions at structural and functional levels, pertinent to understanding cellular mechanisms of graft action both in the basic neuroscience and in the clinical setting, where 6-l-[18F]fluorodopa uptake is used to monitor the survival of human mesencephalic grafts in Parkinsonian patients.4,5
Additional chapters from this book:
Directions for Future Research
Lazaros C. Triarhou
Our groundwork, first, introduced and characterized in detail the weaver mouse as a model of spontaneous progressive dopamine (DA) deficiency similar to Parkinson's disease, and secondly, l...
Behavioral Recovery of Functional Responses
Lazaros C. Triarhou
Studies in rats have shown that unilateral destruction of the nigrostriatal pathway by 6-hydroxydopamine (6-OHDA) results in a spontaneous rotational bias to the side ipsilateral to the les...
Neurochemical Indices of Functional Restoration
Lazaros C. Triarhou
A general asset of the weaver model is that one can study graft development at the same time as the animal's own dopamine (DA) system continues to undergo a progressive degeneration, which is ...
Structural Correlates of Process Outgrowth and Circuit Reconstruction
Lazaros C. Triarhou
Certain cellular mechanisms by which grafts promote recovery in experimental animals have been deciphered.1,2 It has been suggested that a multitude of trophic, neurohumoral and ...
Histochemical Properties of Intrastriatal Mesencephalic Grafts
Lazaros C. Triarhou
The rationale behind neural transplantation studies using the weaver mouse model has been to replace degenerated neurons that are lost in the neurogenetic disease by intracerebrally grafted fe...
Biology and Pathology of the Weaver Mutant Mouse
Lazaros C. Triarhou
The weaver mutant mouse (wv/wv) is characterized by a genetically-induced degeneration of mesostriatal dopamine (DA) neurons. In that sense, it can be viewed as a pathophysiological phenoco...
Introduction
Lazaros C. Triarhou
Dopamine and Parkinson's Disease
Movement control is accomplished by complex interactions among various groups of nerve cells in the central nervous system. One such important group ofneurons...
