Chapter category: Cell Cycle
Activation of CDKs by CAK: CAK in TFIIH
The CDK-Activating Kinase (CAK)
Edited by: Philipp KaldisISBN: 0-306-47438-7
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Chapter authors:
Anne Keriel and Jean-Marc Egly
TFIIH was originally identified as a basal transcription factor involved in protein-coding genes transcription.1,2 The systematic cloning of its nine subunits revealed however that TFIIH also participates in two other fundamental cell processes: cell cycle regulation and repair of damaged DNA. Because TFIIH is involved in more than one cellular process, mutations in some of its subunits can lead to human syndromes : Xeroderma pigmentosum, Trichothiodystrophy and Cockayne syndrome.3,4 These genetic disorders are caracterized by complex phenotypes with large ranges of pleiotropic symptoms, including UV-light sensitivity, cancer susceptibilities and developmental abnormalities.
In this study, we will describe the function(s) of a ternary subcomplex of TFIIH, named « CAK » (CDK-activating kinase) because of its ability to activate CDKs by phosphorylation, keeping in mind that TFIIH possesses additional enzymatic activities involved in both RNA synthesis and DNA repair.
Additional chapters from this book:
Structural Aspects of CDK Activation
Nick R. Brown and Jane A. Endicott
Sequential activation of members of the cyclin-dependent kinase (CDK) family orders the events required for DNA replication and cell division. Both the CDK and cyclin families ha...
Activation of CDKs by CAK: CAK in TFIIH
Anne Keriel and Jean-Marc Egly
TFIIH was originally identified as a basal transcription factor involved in protein-coding genes transcription.1,2 The systematic cloning of its nine subunits r...
CDK-Activation in Fission Yeast Schizosaccharomyces pombe: Specificity Mediated
Thomas Westerling, Damien Hermand and Tomi P. Mäkelä
Activation of cyclin dependent kinases (CDKs) by phosphorylation of the conserved Tloop is a regulatory step of cell cycle progression that was discovered just a decade ago. A we...
Activating Phosphorylation of Cyclin-Dependent Kinases in Budding Yeast
Philipp Kaldis, Vasiliki Tsakraklides, Karen E. Ross, Edward Winter
The eukaryotic cell division cycle is controlled via the sequential activation and inactivation of cyclin-dependent protein kinases (cdks). In the budding yeast Sacchar...
CDK-Activating Kinases in Higher Plants
Masaaki Umeda
Recent development in plant molecular genetics has facilitated our understanding of how plants accomplish their body plans in response to various environmental signals. Plants h...
Drosophila CDK7: A Paradigm for CAK in Metazoans
Stéphane Larochelle and Robert P. Fisher
Activation of cyclin dependent kinases (CDKs) by phosphorylation of the conserved Tloop is a regulatory step of cell cycle progression that was discovered just a decade ago. A wealth o...
The Evolution of CDK-Activating Kinases
Ji Liu, Edward T. Kipreos
Cyclin-dependent kinases (CDKs) are essential regulators of the cell cycle and transcription. In the budding yeast Saccharomyces cerevisiae and the fission ...
CAK from Marine Invertebrates to Human
Randy Y.C. Poon
The eukaryotic cell cycle is driven by an evolutionarily conserved engine consisting of a series of cyclin-dependent kinase (CDK)-cyclin modules. The orderly events of the cell cyc...
