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Chapter category: Neurodegenerative Disease

Alzheimer Disease—A New Beginning, or a Final Exit?

This chapter appears in the following book:

Cell-Cycle Mechanisms and Neuronal Cell Death

Edited by: Agata Copani and Ferdinando Nicoletti
ISBN: 0-306-47850-1
» Get more information about this book at landesbioscience.com «

Chapter authors:
Mark E. Obrenovich, Arun K. Raina, Osamu Ogawa, Craig S. Atwood, Laura Morelli and Mark A. Smith


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Today, a new chapter is being written in the book of Alzheimer disease, one that is challenging the longstanding view that adult neurons are incapable of division, remain nonproliferative, and are terminally differentiated. Here, we review the provocative notion that, in Alzheimer disease, whole populations of non-stem cell neurons leave their quiescent state and re-enter into the cell cycle. However, such neuronal re-entry into the cell cycle is futile and ultimately leads to the neurodegeneration that typifies Alzheimer disease.

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Additional chapters from this book:

Alzheimer Disease: A New Beginning or a Final Exit?

Mark E. Obrenovich, Arun K. Raina, Osamu Ogawa, Craig S. Atwood, Laura Morelli and Mark A. Smith

Today, a new chapter is being written in the book of Alzheimer disease, one that is challenging the longstanding view that adult neurons are incapable of division, remain nonproliferative, and are t...

Cell Cycle Activation in Neurons: The Final Exit of Brain Morpho-Dysregulation

Thomas Arendt

Mammalien cells act and react within frameworks of defined cellular programmes such as division, movement, adhesion, differentiation and death, integrating both genetic and epigenetic information. E...

Cell Cycle and Chromosome Segregation Defects in Alzheimer’s Disease

Huntington Potter

Despite a common set of hallmark neuropathological lesions and clinical symptoms, Alzheimer’s disease has an apparently complex etiology. The disease can be caused by autosomal dominant mutations ...

Cell Cycle Activation and Cell Death in the Nervous System

Zsuzsanna Nagy

The discovery of the cell division cycle opened new avenues for the understanding of cancer as well as in the search for therapy. However, the implications of the discovery had a more profound effec...

The Role of Presenilins in the Cell Cycle and Apoptosis

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Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, affecting approximately 10% of individuals by 65 years of age and 47% by 85 years of age. Whereas the majority of AD c...

Paved with Good Intentions: The Link Between Cell Cycle and Cell Death in the Mammalian Central Nervous System

Yan Yang and Karl Herrup

Cell division is among the most basic of biological processes. All life forms, from blue-green algae to human hepatocytes, ultimately depend for their survival on the ability of one cell to create t...

Alzheimer Disease—A New Beginning, or a Final Exit?

Mark E. Obrenovich, Arun K. Raina, Osamu Ogawa, Craig S. Atwood, Laura Morelli and Mark A. Smith

Today, a new chapter is being written in the book of Alzheimer disease, one that is challenging the longstanding view that adult neurons are incapable of division, remain nonproliferative, and...


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