Chapter category: Heart
Metabolic Support for the Heart During Ischemia and Reperfusion: Role of Amino Acids
Ischemia-Reperfusion Injury in Cardiac Surgery
Edited by: Friedhelm BeyersdorfISBN: 1-58706-002-7
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Chapter authors:
Heinrich Taegtmeyer and Torsten Doenst
In reviewing amino acid metabolism of the heart during ischemia and reperfusion it is important to address a few principles of energy substrate metabolism first. The healthy human heart has a very high rate of energy turnover. Like all living cells, cardiac myocytes need the energy captured in ATP to power their essential functions. The bulk of it is derived from oxidative phosphorylation of ADP, which, in turn, is fueled by oxidation of substrates such as fatty acids, glucose, glycogen, lactate, and certain amino acids. The normal human heart, which weighs about 300 g, consumes about 5 kg of ATP in the course of 24 hours, i.e., 17 times its own weight!1 Under normal conditions most of the energy for contraction is derived from the oxidation of long-chain fatty acids,2 but inotropic stimulation results in the preferential oxidation of glycogen.3 The heart oxidizes amino acids only when their plasma concentrations are very high.4
Additional chapters from this book:
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Metabolic Support for the Heart During Ischemia and Reperfusion: Role of Amino Acids
Heinrich Taegtmeyer and Torsten Doenst
In reviewing amino acid metabolism of the heart during ischemia and reperfusion it is important to address a few principles of energy substrate metabolism first. The healthy human heart has a ...
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Ischemia-reperfusion injury is a common condition during cardiac surgery. Myocardial performance within the first hours after the surgical procedure determines the patient's state not only dur...
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In cardiac surgery, there are numerous opportunities during the conduct of the operation for both unplanned and hence unprotected ischemia with subsequent reperfusion. These periods of potenti...
