Chapter category: BioMaterials
Tissue Engineering Constructs and Commercialization
Biomaterials in the Design and Reliability of Medical Devices
Edited by: Michael N. HelmusISBN: 0-306-47690-8
» Get more information about this book at landesbioscience.com «
Chapter authors:
Kelvin G.M. Brockbank
Tissue engineering is an interdisciplinary field that applies the principles of engineering (materials science and biomedical engineering) and the life sciences (biochemistry, genetics, cell and molecular biology) to the development of biological substitutes that can restore, maintain, or improve tissue functions. In its broader definition, tissue engineering includes isolated cells, tissue-inducing substances, and cells placed on or within matrices. However, in this instance the discussion of tissue engineering is limited to the development, design and implantation of devices consisting of matrices in association with cells, which can migrate, differenciate and perform normal cell/tissue functions. The matrices can be fashioned from natural materials such as collagen or from synthetic polymers. The cellular components may be of human or animal origin, with or without genetic modification. The purpose of this chapter is to present some of the key commercialization issues which exist in the new field of tissue engineering and consider how to utilize these as potential business opportunities. The largest market for tissue engineered products is replacement of structurally or physiologically deficient or diseased tissues and organs in humans. The potential markets for tissue engineered products vary extremely both in size and degree of market development. For example, a recent report1 indicated that the heart valve replacement and skin repair product markets have maximum potential market sizes of $225 and $5,945 million, respectively. Because the heart valve market is well developed, new products must compete with existing products for market share. In contrast, the skin market is virtually untapped, with room for many new products for a variety of clinical indications. Revenues in the total market are anticipated to grow at double-digit rates for the next five years,1 making this a potentially rewarding field for investment. Tissue engineering may eventually address diseases and disorders which account for approximately half of current annual U.S. health care costs, which are estimated to be approximately one trillion dollars at this time.2-5
Additional chapters from this book:
Testing of Biomaterials Modified with Bioactive Molecules: A Case Study
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The majority of medical devices available today are manufactured of relatively inert materials to discourage aggressive biological responses. It has become clear in the last decade or more that the ...
Testing of Biomaterials Modified with Bioactive Molecules: A Case Study
Katherine S. Tweden
The majority of medical devices available today are manufactured of relatively inert materials to discourage aggressive biological responses. It has become clear in the last decade or more that the ...
Tissue Engineering Constructs and Commercialization
Kelvin G.M. Brockbank
Tissue engineering is an interdisciplinary field that applies the principles of engineering (materials science and biomedical engineering) and the life sciences (biochemistry, genetics, cell and mol...
Product Development in a Small Company Environment
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Biomaterials include a broad range of materials that must meet stringent and diverse requirements to be acceptable for use in the body and to meet the needs of specific devices. Biomaterials can be ...
