Cytokines/Growth Factors
Chapters
« previous | page 3 of 3 pagesThe Role of the IGF System in Prostate Cancer
Charles T. Roberts, Jr.
An important aspect of the IGF system in postnatal human physiology is its involvement in tumorigenesis. This was hardly unexpected, based upon the demonstrated role of IGF-I, in particular, as a potent growth regulator. Reports over the last several years of a strong association of circulatin...
The Structure of the Type 1 Insulin-Like Growth Factor Receptor
Colin W. Ward, Thomas P. J. Garrett, Mei Lou, Neil M. McKern, Timothy E. Adams, Thomas C. Elleman, Peter A. Hoyne, Maurice J. Frenkel, Leah J. Cosgrove, George O. Lovrecz, Lindsay G. Sparrow, Lynne Lawrence and V. Chandana Epa
The type 1 insulin-like growth factor receptor (IGF-1R) is widely expressed across many cell types in fetal and postnatal tissues. Signalling through the IGF-1R is the principal pathway responsible for somatic growth in fetal mammals, while somatic growth in postnatal animals is achieved through ...
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