Angiogenesis
Chapters
page 1 of 2 pages | next »Angiogenesis and Ischemia
Derrick S. Grant and Zofia Zukowska-Grojec
The vascular supply to limbs and peripheral tissues is essential for normal physiological functions. Under certain pathologic conditions, however, vascular supply may be reduced to such an extent that it leads to necrosis of the tissue.1 Angiogenesis, the process of new vessel...
Anti-Angiogenesis Strategies: Potential Therapeutic Implications
Shaker A. Mousa
Angiogenesis is a process that is dependent upon coordinate production of angiogenesis stimulatory and inhibitory (angiostatic) molecules and any imbalance in this regulatory circuit might lead to the development of a number of angiogenesis-mediated diseases. Angiogenesis is a...
Crosstalk Between VEGF and Bcl-2 in Tumor Progression and Angiogenesis
Donatella Del Bufalo, Daniela Trisciuoglio and Michele Milella
The study of genes involved in angiogenesis allows clarification of molecular and cellular events related to this phenomenon, as well as identification of new prognostic markers and new targets for cancer therapy. In this review we describe the relevance of the bcl-2 gene in the expression of ...
Effects of Fibrinogen and Associated Peptide Fragments on the Activation of Human Endothelial Cells by VEGF in Vitro
Carolyn A. Staton, Nicola J. Brown and Claire E. Lewis
Angiogenesis, the development of new blood vessels from existing vasculature involves the migration, proliferation and differentiation of endothelial cells and is crucial for the growth and metastasis of tumors. Vascular endothelial growth factor (VEGF), also known as vascular permeability factor...
Hypoxic Regulation of VEGF
Nina S. Levy, Ilana Goldberg-Cohen and Andrew P. Levy
The induction of VEGF is an important step in the angiogenic response to hypoxia. Molecular studies have determined that VEGF is regulated primarily at the level of the mRNA. Specifically, hypoxia leads to an increase in the transcription of VEGF as well as an increase in the stability of the mes...
Integrin av in Health and Disease—Role of avb3 in Metastasis, Vascular Remodeling and Angiogenesis
Shaker A. Mousa, Judith A. Varner and David Cheresh
The invasion, migration, proliferation and survival of cells are now known to be regulated in part by members of the integrin family of cell adhesion proteins. The integrin family is composed of 15 alpha and 8 beta subunits that are expressed in over 20 different ab heterodimeric combina...
Lessons from Clinical Trials of Anti-Angiogenic Drugs in the Treatment of Cancer
Maggie C. Lee, James Tomlinson and Mai Nguyen
The process of angiogenesis plays a critical role in tumor growth and metastasis. Recently, there has been much interest in the use of antiangiogenic drugs in the treatment of cancer. This chapter will review the results of phase I clinical trials of various antiangiogenic agents, and wi...
Matrix Metalloproteinase Inhibitors in Angiogenesis-Mediated Disorders with Special Emphasis on Cancer
Henrik S. Rasmussen
Matrix metalloproteinases (MMPS) are a family of enzymes that are secreted by connective tissue cells, inflammatory phagocytes and a number of different transformed cells. They are called metallo as they all contain a zinc atom at their active site. Under normal physiologic ci...
Mechanisms of Angiogenesis: Potential Therapeutic Targets
Shaker A. Mousa
The formation of new capillary blood vessels, a process termed "angiogenesis", is dependent upon coordinate production of angiogenesis promoters and suppressors. Angiogenesis is an important event in a variety of physiological angiogenesis processes including ovulation, e...
Molecular Mechanisms of VEGF-Induced Angiogenesis
Sandra Donnini, Marina Ziche and Lucia Morbidelli
Angiogenesis is a complex process that occurs in a series of inter-related steps, and involves the release of pro-angiogenic factors. One of the most important angiogenic factors is vascular endothelial growth factor (VEGF). VEGF regulates both vascular endothelial cell migration, proliferation a...
Ocular Neovascularization
Peter A. Campochiaro and Naba Bora
Angiogenesis plays a critical role in embryonic development, the menstrual cycle, and wound repair. Exaggeration of its role in wound repair can result in pathologies such as retinal and choroidal neovascularization. While these disease processes may share some features with neovasculari...
PECAM-1 and Angiogenesis
Horace M. DeLisser
Angiogenesis, the formation of new vessels from a preexisting vasculature depends critically on the ability of the capillary endothelial cells to sever their normal cellcell associations, to migrate through extracellular matrix, and to reform their cellcell attachments to generate new ca...
Pharmaceutical Development of an Antiangiogenic Drug-Candidate: Challenges and Opportunities
Marc Riviére, Violetta Dimitriadou, Gerald Batist and Éric Dupont
The development of antiangiogenic multifunctional drugs aims to make available to physicians and their patients a novel and effective therapy directly targeting angiogenesis-dependent pathologies for which current therapies are not optimal because of toxic effects or of only moderate eff...
Regulation of Angiogenesis by Fibroblast Growth Factors
Carla Mouta Carreira, Francesca Tarantini, Igor Prudovsky, Susan Garfinkel and Thomas Maciag
Polypeptide factors which directly influence the migratory and proliferative activity of the human endothelial cell in vitro are well recognized as mediators of human angiogenesis in vivo. It is also well recognized that members of the fibroblast growth factor (FGF) gene family are not o...
Role of Angiogenesis in Wound Healing
Hynda K. Kleinman and Katherine M. Malinda
Angiogenesis, the formation of new blood vessels, is necessary for wound repair since the new vessels provide nutrients to support the active cells, promote granulation tissue formation and facilitate the clearance of debris.13 Approximately 60% of the granulation t...
Surrogate Endpoints as a Measure of Efficacy in Clinical Trials of Angiogenesis Inhibitors
Przemek Twardowski, Stephen Gately and William Gradishar
It is now generally accepted that solid tumor growth and metastases are dependent upon the acquisition of an adequate blood supply.1 Pharmacological targeting of tumor microvasculature in patients with malignant neoplasms represents an attractive therapeutic approach because i...
Targeting VEGF in Pancreatic Cancer
Cheryl H. Baker, Carmen C. Solorzano and Isaiah J. Fidler
The progressive growth and metastasis of neoplasms, including pancreatic cancers, depend, in part, on angiogenesis, the extent of which is determined by the balance between pro-angiogenic and anti-angiogenic molecules released by tumor cells and normal host cells. Since vascular endothelial growt...
The Role of Smooth Muscle Cells and Pericytes in Angiogensis
Jennifer W. Walter and David C. Sane
The stages of angiogenesis have been defined on the basis of critical endothelial cell activities such as basement membrane proteolysis, cell migration, proliferation and tube formation.1 Moreover, in vitro experiments have shown that endothelial cells alone contain all of the...
The Role of Vascular Endothelial Growth Factor in Angiogenesis
Napoleone Ferrara
The development of a vascular supply is a fundamental requirement for organ development and differentiation during embryogenesis as well as for wound healing and reproductive functions in the adult.1 Angiogenesis is also implicated in the pathogenesis of a variety of disorders...
Thrombospondin and Angiogenesis
Luisa A. DiPietro
Thrombospondin1 (TSP1) is an extracellular matrix molecule that is produced by numerous cell types, including endothelial cells, fibroblasts, macrophages, monocytes, keratinocytes, and some tumor cells.1,2 TSP1 was first described as protein associated with thrombin...
Vascular Endothelial Growth Factor (VEGF) and Its Role in Non-Endothelial Cells: Autocrine Signalling by VEGF
Angela M. Duffy, David J. Bouchier-Hayes and Judith H. Harmey
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor and was first described as an essential growth factor for vascular endothelial cells. VEGF is up-regulated in many tumors and its contribution to tumor angiogenesis is well defined. In addition to endothelial cells, VEGF and ...
Vascular Endothelial Growth Factor C and Vascular Endothelial Growth Factor D: Biology, Functions and Role in Cancer
Sarah E. Duff and Gordon C. Jayson
Vascular Endothelial Growth Factors (VEGF)-C and VEGF-D are angiogenic and lymphangiogenic members of the VEGF family. These two growth factors form a subgroup by virtue of their structural and functional similarities. VEGF-C and VEGF-D are ligands for VEGF receptors, VEGFR-2 and VEGFR-3 and sign...
Vascular Endothelial Growth Factor in Breast Cancer
Tilmann Lantzsch and Lukas Hefler
Breast cancer, as with most solid tumors, needs to develop the angiogenic phenotype for invasiveness, progression and metastasis. Several studies have determined that the degree of peritumoral vascularity as a marker of angiogenesis is associated with prognosis of patients operated on for early s...
Vascular Endothelial Growth Factor in Malignant Disease of the Central Nervous System
David Stefanik
Vascular Endothelial Growth Factor (VEGF) is a major contributor to the growth of malignant tumors of the central nervous system. It stimulates tumor angiogenesis and vascular proliferation characteristic of high grade gliomas. Elevated expression of VEGF is one the factors responsible for the vi...
VEGF and Its Receptors
Napoleone Ferrara
The development of a vascular supply is a highly complex process. Work done over the last decade has elucidated the critical role of vascular endothelial growth factor (VEGF) in the regulation of normal and pathological angiogenesis. The activities of VEGF are mediated by two tyrosine kinase rece...
page 1 of 2 pages | next »
