Safety Considerations in Vector Development

John C. Kappes and Xiaoyun Wu

The inadvertent production of replication competent retrovirus (RCR) constitutes the principal safety concern for the use of lentiviral vectors in human clinical protocols. Because of limitations in animal models to evaluate lentiviral vectors for their potential to recombine and induce ...

Strategies to Adapt Adenoviral Vectors for Gene Therapy Applications

Joanne T. Douglas, Meizhen Feng, and David T. Curiel

The Generation of Targeted Adenoviral Vectors by Immunological Modifications of the Fiber Protein

Full utility of adenoviral vectors is potentially undermined by their broad tropism profile. In this regard, for gene therapy purposes it would be desirable to derive adenoviral ...

Transcriptional and Promoter–Driven Control of Adenovirus–Mediated

Yoko Yoshida and Hirofumi Hamada

Transcriptionally targeted adenoviral vectors which are able to restrict and regulate the levels of expression of the therapeutic gene will have wide applicability for gene therapy. For cancer gene therapy, tumor–specific promoters could be used to drive drug sensitivity genes (e.g....