Structure Distribution and Function of a10b1

Evy Lundgren-Åkerlund and Max Schneller

Introduction The integrin a10b1 was originally identified as a collagen type II binding integrin on chondrocytes.1 The bovine integrin subunit a10 was isolated from chondrocyte lysates by affinity chromatogr...

The CRMP Family of Proteins and Their Role in Sema3A Signaling

The CRMP proteins were originally identified as mediators of Sema3A signaling and neuronal differentiation. Much has been learned about the mechanism by which CRMPs regulate cellular responses to Sema3A. In this review, the evidence for CRMP as a component of the Sema3A signaling cascade and the mod...

The Treatment of Acromegaly with Somatostatin Analogs

Nuria Sucunza, Mª José Barahona and Susan M. Webb

Although transsphenoidal surgery of pituitary micro or macroadenomas is the treatment of choice in most acromegalic patients, somatostatin analogs are the first choice for medical treatment, either primary or secondary. Nowadays, two forms of octreotide, s.c. short- and i.m. long-acting, and t...